Posts
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What is a reversible terminator in DNA sequencing?
To identify the sequence in DNA, each base in a DNA fragment or DNA nanoball needs to be identified step-by-step. First, a primer binds to the adaptor in the DNA strand, and the primer will be extended using an artificial dNTP rather than a natural dNTP. The artificial dNTP usually prevents further extension, so one…
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What is the DNA sequencing platform, MGI-seq or DNB-seq?
MGI-seq or DNB-seq is a next-generation sequencing (NGS) platform developed by MGI Tech Co., Ltd. It could perform whole-genome sequencing (WGS), sequencing of cell-free DNA fragments (cfDNA), ATAC-Seq, etc. It is also a form of sequencing by synthesis (SBS) technology. But different from Illumina sequencing which utilizes bridge amplification, DNB-Seq requires the rolling circle amplification…